Nature Communications (Aug 2021)
Comprehensive mapping of SARS-CoV-2 interactions in vivo reveals functional virus-host interactions
- Siwy Ling Yang,
- Louis DeFalco,
- Danielle E. Anderson,
- Yu Zhang,
- Jong Ghut Ashley Aw,
- Su Ying Lim,
- Xin Ni Lim,
- Kiat Yee Tan,
- Tong Zhang,
- Tanu Chawla,
- Yan Su,
- Alexander Lezhava,
- Andres Merits,
- Lin-Fa Wang,
- Roland G. Huber,
- Yue Wan
Affiliations
- Siwy Ling Yang
- Epigenetic and Epitranscriptomic Regulation, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR)
- Louis DeFalco
- Biomolecular Function Discovery, Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Matrix #07-01
- Danielle E. Anderson
- Programme in Emerging Infectious Diseases, Duke-NUS Medical School
- Yu Zhang
- Epigenetic and Epitranscriptomic Regulation, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR)
- Jong Ghut Ashley Aw
- Epigenetic and Epitranscriptomic Regulation, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR)
- Su Ying Lim
- Epigenetic and Epitranscriptomic Regulation, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR)
- Xin Ni Lim
- Epigenetic and Epitranscriptomic Regulation, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR)
- Kiat Yee Tan
- Epigenetic and Epitranscriptomic Regulation, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR)
- Tong Zhang
- Epigenetic and Epitranscriptomic Regulation, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR)
- Tanu Chawla
- Programme in Emerging Infectious Diseases, Duke-NUS Medical School
- Yan Su
- Laboratory of translational diagnostics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR)
- Alexander Lezhava
- Laboratory of translational diagnostics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR)
- Andres Merits
- Institute of Technology, University of Tartu
- Lin-Fa Wang
- Programme in Emerging Infectious Diseases, Duke-NUS Medical School
- Roland G. Huber
- Biomolecular Function Discovery, Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Matrix #07-01
- Yue Wan
- Epigenetic and Epitranscriptomic Regulation, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR)
- DOI
- https://doi.org/10.1038/s41467-021-25357-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Here, Yang et al. apply different RNA sequencing approaches to characterize the secondary structure of SARS-CoV-2 viral RNAs, report on long-range interactions along the viral genome, and uncover the virus-host RNA interactome in cells.
