Towards a systematic understanding of cancers: a survey of the pan-cancer study

Abstract

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Studies on molecular aberrations of cancer patients have increased unprecedentedly in scale and accessibility, allowing large-scale integrative cross-cancer analysis. Pan-cancer study is becoming a valuable paradigm for cancer genomics. Here, we review recent advances in this field and highlight the potential challenges and directions especially from the computational angle.

Keywords

• bioinformatics
• Cancer genomics
• data integration
• The Cancer Genome Atlas.
• pan-cancer study