Nature Communications (Nov 2018)
MAIT cells contribute to protection against lethal influenza infection in vivo
- Bonnie van Wilgenburg,
- Liyen Loh,
- Zhenjun Chen,
- Troi J. Pediongco,
- Huimeng Wang,
- Mai Shi,
- Zhe Zhao,
- Marios Koutsakos,
- Simone Nüssing,
- Sneha Sant,
- Zhongfang Wang,
- Criselle D’Souza,
- Xiaoxiao Jia,
- Catarina F. Almeida,
- Lyudmila Kostenko,
- Sidonia B. G. Eckle,
- Bronwyn S. Meehan,
- Axel Kallies,
- Dale I. Godfrey,
- Patrick C. Reading,
- Alexandra J. Corbett,
- James McCluskey,
- Paul Klenerman,
- Katherine Kedzierska,
- Timothy S. C. Hinks
Affiliations
- Bonnie van Wilgenburg
- Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Liyen Loh
- Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Zhenjun Chen
- Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Troi J. Pediongco
- Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Huimeng Wang
- Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Mai Shi
- Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Zhe Zhao
- Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Marios Koutsakos
- Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Simone Nüssing
- Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Sneha Sant
- Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Zhongfang Wang
- Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Criselle D’Souza
- Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Xiaoxiao Jia
- Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Catarina F. Almeida
- Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Lyudmila Kostenko
- Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Sidonia B. G. Eckle
- Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Bronwyn S. Meehan
- Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Axel Kallies
- Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Dale I. Godfrey
- Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Patrick C. Reading
- Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Alexandra J. Corbett
- Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- James McCluskey
- Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Paul Klenerman
- Peter Medawar Building for Pathogen Research and Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, University of Oxford
- Katherine Kedzierska
- Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Timothy S. C. Hinks
- Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- DOI
- https://doi.org/10.1038/s41467-018-07207-9
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 9
Abstract
MAIT cells are abundant in the lungs and confer protection against bacterial pathogens. Whilst activation of these cells has been described during viral infections, here van Wilgenburg and colleagues show that in a murine model MAIT cells contribute to the protective host immune response to influenza virus infection.
