Prognosis of unfavorable course of ulcerative colitis as indication for anticytokine therapy

Abstract

Aim of investigation. To outline predictive model for unfavorable course of ulcerative colitis (UC).Material and methods. Overall 232 patients with UC were included in original study, 84 of them had favourable and 148 – unfavorable course of disease.Results. Prognostic system for various variants of course of UC and its complications, 27 most significant clinical signs of disease based on differentiated clinical and statistical evaluation was submitted. To define indications for «top down» therapy with application of TNF-α blockers clinically approved algorithm of prognostic decisions for development of favorable (uncomplicated, rarely relapsing) and unfavorable (frequently relapsing, continuous, steroiddependent) variants of disease, and its complications was stated. Basing on high scores of sensitivity (accuracy) and specificity of prognosis, that were received, data proving potential of indications for early anticytokine treat­ment by infliximab to avoid unfavorable course and complications of ulcerative colitis are presented.

Keywords

• ulcerative colitis
• prognosis
• anticytokine therapy