PLoS ONE (Jan 2015)

Binding Patterns of Rotavirus Genotypes P[4], P[6], and P[8] in China with Histo-Blood Group Antigens.

  • Xin Ma,
  • Dan-di Li,
  • Xiao-Man Sun,
  • Yan-Qing Guo,
  • Jing-Yao Xiang,
  • Wei-Huan Wang,
  • Li-Xia Zhang,
  • Qing-Jiu Gu,
  • Zhao-Jun Duan

DOI
https://doi.org/10.1371/journal.pone.0134584
Journal volume & issue
Vol. 10, no. 8
p. e0134584

Abstract

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Rotaviruses (RVs) are an important cause of severe gastroenteritis in children. It has been found that RV may recognize the histo-blood group antigens (HBGAs) as ligands or receptors and bind HBGAs in a type-dependent manner. In this study, we investigated the binding specificity of VP8* proteins from human rotaviruses (RV) that are prevalent in China including genotypes P[4], P[6], and P[8]. Through the saliva- and oligosaccharide-based binding assays, we found that the VP8* proteins of P[4] and P[8] RV showed similar reactivity with the Leb and H type 1 antigens, while P[6] RV weakly bound the Leb antigen. These findings may facilitate further research into RV host specificity and vaccine development.