Worth it or not? Primary tumor resection for stage IV pancreatic cancer patients: A SEER‐based analysis of 15,836 cases

Abstract

Abstract Background Primary tumor resection (PTR) as a treatment option for patients with stage IV pancreatic cancer (PC) is controversial. Patients and methods Stage IV PC patients, with treatment data from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER), were screened. The main outcomes were overall survival (OS) and cancer‐specific survival (CSS). Results We enrolled 15,836 stage IV PC patients in this study. Propensity score‐matched analyses revealed improved OS and CSS of patients receiving chemotherapy plus PTR versus chemotherapy (median survival time [MSTOS]: 13 vs. 9 months, p = 0.024; MSTCSS: 14 vs. 10 months, p = 0.035), and chemoradiotherapy plus PTR versus chemoradiotherapy (MSTOS: 14 vs. 7 months, p = 0.044; MSTCSS: 14 vs. 7 months, p = 0.066). Multivariate adjusted analyses further confirmed these results. Stratified with different metastatic modalities, multivariate analyses suggested that PTR significantly improved the OS and CSS among patients with ≤1 metastatic organ, and that patients with brain metastasis might not benefit from chemotherapy treatment. Conclusion PTR improves the OS and CSS of stage IV PC patients on the basis of chemotherapy or chemoradiotherapy, provided that the metastases involve ≤1 organ. Chemotherapy, however, should be carefully considered in patients with metastases involving the brain.

Keywords

• cancer‐specific survival (CSS)
• metastatic disease
• overall survival (OS)
• pancreatic cancer (PC)
• primary tumor resection (PTR)