Structure of the homodimeric androgen receptor ligand-binding domain

Marta Nadal; Stefan Prekovic; Nerea Gallastegui; Christine Helsen; Montserrat Abella; Karolina Zielinska; Marina Gay; Marta Vilaseca; Marta Taulès; Adriaan B. Houtsmuller; Martin E. van Royen; Frank Claessens; Pablo Fuentes-Prior; Eva Estébanez-Perpiñá

doi:10.1038/ncomms14388

Nature Communications (Feb 2017)

Structure of the homodimeric androgen receptor ligand-binding domain

Marta Nadal,
Stefan Prekovic,
Nerea Gallastegui,
Christine Helsen,
Montserrat Abella,
Karolina Zielinska,
Marina Gay,
Marta Vilaseca,
Marta Taulès,
Adriaan B. Houtsmuller,
Martin E. van Royen,
Frank Claessens,
Pablo Fuentes-Prior,
Eva Estébanez-Perpiñá

Affiliations

Marta Nadal: Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine (IBUB) of the University of Barcelona (UB)
Stefan Prekovic: Molecular Endocrinology Laboratory, KU Leuven
Nerea Gallastegui: Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine (IBUB) of the University of Barcelona (UB)
Christine Helsen: Molecular Endocrinology Laboratory, KU Leuven
Montserrat Abella: Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine (IBUB) of the University of Barcelona (UB)
Karolina Zielinska: Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine (IBUB) of the University of Barcelona (UB)
Marina Gay: Mass Spectrometry Core Facility, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST)
Marta Vilaseca: Mass Spectrometry Core Facility, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST)
Marta Taulès: Unitat de Citometria, Centres Científics I Tecnològics (CCIT), Universitat de Barcelona (UB)
Adriaan B. Houtsmuller: Department of Pathology, Erasmus MC
Martin E. van Royen: Department of Pathology, Erasmus MC
Frank Claessens: Molecular Endocrinology Laboratory, KU Leuven
Pablo Fuentes-Prior: Bases Estructurals de Processos Fisiopatològics Fonamentals, 2014-SGR-01214, Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR)
Eva Estébanez-Perpiñá: Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine (IBUB) of the University of Barcelona (UB)

DOI: https://doi.org/10.1038/ncomms14388
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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The androgen receptor is crucial for the development and physiology of reproductive organs. Here the authors present the structure of the androgen receptor ligand-binding domain bound to dihydrotestosterone, identifying a homodimerization interface that is crucial for receptor activityin vivo.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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