Nature Communications (Nov 2022)

Osteocytes directly regulate osteolysis via MYD88 signaling in bacterial bone infection

  • Tetsuya Yoshimoto,
  • Mizuho Kittaka,
  • Andrew Anh Phuong Doan,
  • Rina Urata,
  • Matthew Prideaux,
  • Roxana E. Rojas,
  • Clifford V. Harding,
  • W. Henry Boom,
  • Lynda F. Bonewald,
  • Edward M. Greenfield,
  • Yasuyoshi Ueki

DOI
https://doi.org/10.1038/s41467-022-34352-z
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 19

Abstract

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MYD88 mediates the signal of bacterial infection. Here, in the context of periodontal infection, the authors show that the MYD88 pathway in osteocytes plays a dominant role in regulating osteolysis.