Química Nova (Jun 2020)

A NEW SECO-LIMONOID FROM THE INFLORESCENCES OF Dictyoloma vandellianum

  • Laiane Caline Oliveira Pereira,
  • Lucas Silva Abreu,
  • Mayra Bitencourt Silveira,
  • Yuri Mangueira do Nascimento,
  • Thalisson Amorim de Souza,
  • Mireille Le Hyaric,
  • Thaís Mangeon Honorato Lisboa,
  • Marianna Vieira Sobral,
  • Eudes da Silva Velozo,
  • Josean Fechine Tavares,
  • Marcelo Sobral da Silva

DOI
https://doi.org/10.21577/0100-4042.20170515
Journal volume & issue
Vol. 43, no. 5
pp. 568 – 571

Abstract

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Phytochemical investigation of the inflorescences of Dictyoloma vandellianum A. Juss. (Rutaceae) has led to the isolation of a new A-seco-limonoid, named dictyolomol (1), along with a known quinolone alkaloid, casimiroine (2), previously isolated from the same species. The structures were established by spectroscopic analysis such as one- and two-dimensional NMR, IR, high-resolution mass spectrometry and chemical transformations. The isolated compounds (1 and 2) and O-acetyl derivative (1a) were evaluated for their cytotoxicity against MCF-7 and HeLa cancer cell lines. The results indicated that 1, 1a and 2 showed no significant cytotoxicity.

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