Nature Communications (Aug 2022)
Earlier Alzheimer’s disease onset is associated with tau pathology in brain hub regions and facilitated tau spreading
- Lukas Frontzkowski,
- Michael Ewers,
- Matthias Brendel,
- Davina Biel,
- Rik Ossenkoppele,
- Paul Hager,
- Anna Steward,
- Anna Dewenter,
- Sebastian Römer,
- Anna Rubinski,
- Katharina Buerger,
- Daniel Janowitz,
- Alexa Pichet Binette,
- Ruben Smith,
- Olof Strandberg,
- Niklas Mattsson Carlgren,
- Martin Dichgans,
- Oskar Hansson,
- Nicolai Franzmeier
Affiliations
- Lukas Frontzkowski
- Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich
- Michael Ewers
- Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich
- Matthias Brendel
- Department of Nuclear Medicine, University Hospital, LMU Munich
- Davina Biel
- Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich
- Rik Ossenkoppele
- Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University
- Paul Hager
- Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich
- Anna Steward
- Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich
- Anna Dewenter
- Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich
- Sebastian Römer
- Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich
- Anna Rubinski
- Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich
- Katharina Buerger
- Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich
- Daniel Janowitz
- Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich
- Alexa Pichet Binette
- Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University
- Ruben Smith
- Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University
- Olof Strandberg
- Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University
- Niklas Mattsson Carlgren
- Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University
- Martin Dichgans
- Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich
- Oskar Hansson
- Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University
- Nicolai Franzmeier
- Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich
- DOI
- https://doi.org/10.1038/s41467-022-32592-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Individuals with young onset sporadic Alzheimer’s disease show faster pathological and clinical progression. Here the authors report that earlier symptom onset in Alzheimer’s disease is associated with higher tau pathology in globally connected brain hubs, accelerated connectivity-mediated tau spreading and faster cognitive decline.
