Scientific Reports (Jan 2025)

Post-myocardial infarction ventricular septal defects: incidence and treatment trends during and after the COVID-19 pandemic

  • Giuseppe Nasso,
  • Ignazio Condello,
  • Walter Vignaroli,
  • Andrea Antonazzo,
  • Francesco Bartolomucci,
  • Barbara Pala,
  • Claudio Larosa,
  • Annachiara Pingitore,
  • Vincenzo Amodeo,
  • Vincenzo Montemurro,
  • Mizar D’Abramo,
  • Roberto Ceravolo,
  • Domenica Donato,
  • Pasquale Fratto,
  • Maria Grazia De Rosis,
  • Giuseppe Diaferia,
  • Rita Torraco,
  • Gaetano Contegiacomo,
  • Guido Lembo,
  • Mario Siro Brigiani,
  • Giuseppe Santarpino,
  • Giuseppe Speziale

DOI
https://doi.org/10.1038/s41598-024-84983-z
Journal volume & issue
Vol. 15, no. 1
pp. 1 – 8

Abstract

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Abstract Ventricular septal defect (VSD) is a serious complication of myocardial infarction (MI), with its global incidence significantly reduced in recent years due to advances in coronary reperfusion techniques. However, during the COVID-19 pandemic, there was an unexpected rise in the incidence of post-MI VSD, likely driven by delays in seeking treatment. This study retrospectively analyzed 10 cases of post-MI VSD treated at our hospitals from March 2018 to August 2023, comparing incidence rates across pre-pandemic, pandemic, and post-pandemic periods. The findings revealed a notable increase in VSD cases during the pandemic, with six cases occurring in two years, compared to only two cases in each of the pre-pandemic and post-pandemic periods. Despite these fluctuations, surgical intervention remained a crucial and effective treatment, with 60% of patients surviving the 30-day follow-up. The study underscores the impact of delayed treatment on VSD incidence during the pandemic and highlights the critical need for timely medical intervention to manage severe MI complications effectively.

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