Cohort profile: follow-up of a Berlin Aging Study II (BASE-II) subsample as part of the GendAge study
Maximilian König,
Elisabeth Steinhagen-Thiessen,
Ilja Demuth,
Graham Pawelec,
Peter Eibich,
Kilian Wistuba-Hamprecht,
Andreas Thiel,
Vera Regitz-Zagrosek,
Lars Bertram,
Christina M Lill,
Ulman Lindenberger,
Verena Banszerus,
Johanna Drewelies,
Sandra Düzel,
Ute Seeland,
Dominik Spira,
Esther Tse,
Julian Braun,
Denis Gerstorf,
Nikolaus Buchmann,
Friederike Kendel,
Maike Mangold,
Ahmad Tauseef Nauman,
Kristina Norman,
Sarah Toepfer,
Valentin Max Vetter,
Gert G Wagner,
Ursula Wilkenshoff
Affiliations
Maximilian König
2 Lipid Clinic at the Interdisciplinary Metabolism Center, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
Elisabeth Steinhagen-Thiessen
professor of geriatrics
Ilja Demuth
Department of Endocrinology and Metabolic Diseases (including Division of Lipid Metabolism), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
Graham Pawelec
Health Sciences North Research Institute, Sudbury, Ontario, Canada
Peter Eibich
Kilian Wistuba-Hamprecht
Department of Dermatology, University Hospital Tübingen, Eberhard Karls University of Tübingen, Tübingen, Germany
Andreas Thiel
Si-M / “Der Simulierte Mensch” a science framework of Technische, Universitat Berlin andCharité - Universitatsmedizin Berlin, Berlin, Germany
Vera Regitz-Zagrosek
DZHK (German Centre for Cardiovascular Research), Partner site Berlin, Berlin, Germany
Lars Bertram
Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Massachusetts, USA
Christina M Lill
Ulman Lindenberger
Center for Lifespan Psychology, Max-Planck-Institute for Human Development, Berlin, Germany
Verena Banszerus
Department of Endocrinology and Metabolic Diseases (including Division of Lipid Metabolism), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
Johanna Drewelies
Department of Psychology, Humboldt University of Berlin, Berlin, Berlin, Germany
Sandra Düzel
Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
Ute Seeland
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Social Medicine, Epidemiology and Health Economics, Berlin, Germany
Dominik Spira
Department of Endocrinology and Metabolic Diseases (including Division of Lipid Metabolism), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
Esther Tse
Berlin Institute for Gender in Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
Julian Braun
Si-M / “Der Simulierte Mensch” a science framework of Technische, Universitat Berlin andCharité - Universitatsmedizin Berlin, Berlin, Germany
Denis Gerstorf
Department of Psychology, Humboldt University of Berlin, Berlin, Berlin, Germany
Purpose The study ‘Sex- and gender-sensitive prevention of cardiovascular and metabolic disease in older adults in Germany’, the GendAge study, focuses on major risk factors for cardiovascular and metabolic diseases and on the development of major outcomes from intermediate phenotypes in the context of sex and gender differences. It is based on a follow-up examination of a subsample (older group) of the Berlin Aging Study II (BASE-II).Participants The GendAge study assessments took place between 22 June 2018 and 10 March 2020. A total of 1100 participants (older BASE-II subsample, aged ≥65 years) with baseline data assessed at least by one of the BASE-II partner sites were investigated in the follow-up. These participants had a mean age of 75.6 years (SD ±3.8), with a mean follow-up at 7.4 years (SD ±1.5).Findings to date Data from different domains such as internal medicine, geriatrics, immunology and psychology were collected, with a focus on cardiometabolic diseases and in the context of sex and gender differences. Diabetes mellitus type 2 was reported by 15.6% and 8.6% of men and women, respectively. In contrast, this disease was diagnosed in 20.7% of men and 13.3% of women, indicating that a substantial proportion of almost 30% was unaware of the disease. Echocardiography revealed that left ventricular ejection fraction was higher in women than in men, in agreement with previous reports.Future plans A gender questionnaire assessing sociocultural aspects implemented as part of the follow-up described here will allow to calculate a gender score and its evaluation based on the newly collected data. At the same time, the other BASE-II research foci established over the past 10 years will be continued and strengthened by the BASE-II transition into a longitudinal study with follow-up data on the older subsample.Trial registration number DRKS00016157.
