Nature Communications (Mar 2021)

Genome-wide binding potential and regulatory activity of the glucocorticoid receptor’s monomeric and dimeric forms

  • Thomas A. Johnson,
  • Ville Paakinaho,
  • Sohyoung Kim,
  • Gordon L. Hager,
  • Diego M. Presman

DOI
https://doi.org/10.1038/s41467-021-22234-9
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

Read online

Glucocorticoid receptors (GR) are thought to bind DNA as dimers or monomers, to regulate different transcription pathways. Here, the authors perform genome-wide studies on GRs with mutations that impair dimerization and provide evidence that monomeric GRs do not play a significant physiologic role.