Allograft inflammatory factor 1 is a regulator of transcytosis in M cells

Sari Kishikawa; Shintaro Sato; Satoshi Kaneto; Shigeo Uchino; Shinichi Kohsaka; Seiji Nakamura; Hiroshi Kiyono

doi:10.1038/ncomms14509

Nature Communications (Feb 2017)

Allograft inflammatory factor 1 is a regulator of transcytosis in M cells

Sari Kishikawa,
Shintaro Sato,
Satoshi Kaneto,
Shigeo Uchino,
Shinichi Kohsaka,
Seiji Nakamura,
Hiroshi Kiyono

Affiliations

Sari Kishikawa: Division of Mucosal Immunology, The Institute of Medical Science, The University of Tokyo
Shintaro Sato: Division of Mucosal Immunology, The Institute of Medical Science, The University of Tokyo
Satoshi Kaneto: Division of Mucosal Immunology, The Institute of Medical Science, The University of Tokyo
Shigeo Uchino: Department of Neurochemistry, National Institute of Neuroscience
Shinichi Kohsaka: Department of Neurochemistry, National Institute of Neuroscience
Seiji Nakamura: Division of Maxillofacial Diagnostic and Surgical Sciences, Section of Oral and Maxillofacial Oncology, Faculty of Dental Science, Kyushu University
Hiroshi Kiyono: Division of Mucosal Immunology, The Institute of Medical Science, The University of Tokyo

DOI: https://doi.org/10.1038/ncomms14509
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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M cells are intestinal epithelial cells that are specialized to transcytose antigens and bacteria from the intestinal lumen to antigen presenting cells on the other side. Here the authors show that the actin-binding protein Aif1 is highly expressed by intestinal M cells and regulates this transcytosis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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