Advantages of Porcine Xenograft over Autograft in Sinus Lift: A Randomised Clinical Trial
Francisco Correia,
Daniel Humberto Pozza,
Sónia Gouveia,
António Campos Felino,
Ricardo Faria-Almeida
Affiliations
Francisco Correia
Department of Oral Surgery and Periodontology, Faculty of Dental Medicine, University of Porto, 4200-135 Porto, Portugal
Daniel Humberto Pozza
Department of Biomedicine, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal
Sónia Gouveia
Department of Electronics, Telecommunications and Informatics (DETI), Institute of Electronics and Informatics Engineering of Aveiro (IEETA), University of Aveiro, 3810-193 Aveiro, Portugal
António Campos Felino
Department of Oral Surgery and Periodontology, Faculty of Dental Medicine, University of Porto, 4200-135 Porto, Portugal
Ricardo Faria-Almeida
Department of Oral Surgery and Periodontology, Faculty of Dental Medicine, University of Porto, 4200-135 Porto, Portugal
This study aimed to compare the performance of intra-oral autologous bone grafts versus porcine xenografts in a two-step lateral window sinus lift. This split-mouth randomised controlled trial sequentially enrolled 12 patients with a 6-month follow-up. For each patient, a simultaneous randomised bilateral maxillary sinus lift was performed and filled with autologous bone from the mandible (control) or a porcine xenograft (test). A bone biopsy sample was collected during the implant placement for histological and histomorphometric analysis. CT scans were performed at the beginning and at the end of the trial to assess radiological evolution. A comparison of initial and six-month CT scans indicated statistically significant increases in bone level for both materials (7.8 ± 2.4 mm for autologous and 8.7 ± 2.2 mm for xenograft, p p = 0.26). The histological analysis showed various stages of the remodelling process and no cells or other signs of inflammation or infection were visible in both groups. The porcine xenografts presented similar results for the studied variables when compared to autologous bone, being a reasonable alternative for a sinus lift.