Interrelation between <i>Pseudomonas aeruginosa</i> quinolone signal and the level of immunoglobulins in the blood of patients with lung cancer

Abstract

Introduction. Researchers in the field of oncology have a significant interest in the role of microorganisms in development of malignant neoplasms.Aim. To study the levels of 2-heptyl-3-hydroxy-4-quinolone (PQS) and 2-heptyl-4-quinolone (HHQ) produced by Pseudomonas aeruginosa in the blood of patients with lung cancer and to analyze the relation between their changes and changes in the level of immunoglobulins and vascular endothelial growth factor (VEGF) in the blood of patients with lung cancer.Materials and methods. PQS and HHQ were quantified in the blood of patients using high performance liquid chromatography. The levels of immunoglobulins G (IgG), secretory immunoglobulin A (s-IgA), and VEGF in the blood were determined using ELISA.Results. Analysis have shown that the level of PQS in the blood of patients with lung cancer is 2-fold higher than in the control group. This change is accompanied by a decrease in the level of immunoglobulins IgG, as well as an increase in the content of s-IgA and growth factor VEGF in the blood.Conclusion. PQS level in the blood of patients with lung cancer is elevated creating conditions aggravating the course of the main disease and worsening its prognosis.

Keywords

• lung cancer
• 2-heptyl-3-hydroxy-4-quinolone
• 2-heptyl-4-quinolone
• cytokines
• immunoglobulins
• <i>pseudomonas aeruginosa</i>
• quorum sensing