Cell division drives DNA methylation loss in late-replicating domains in primary human cells

Jamie L. Endicott; Paula A. Nolte; Hui Shen; Peter W. Laird

doi:10.1038/s41467-022-34268-8

Nature Communications (Nov 2022)

Cell division drives DNA methylation loss in late-replicating domains in primary human cells

Jamie L. Endicott,
Paula A. Nolte,
Hui Shen,
Peter W. Laird

Affiliations

Jamie L. Endicott: Department of Epigenetics, Van Andel Institute
Paula A. Nolte: Department of Epigenetics, Van Andel Institute
Hui Shen: Department of Epigenetics, Van Andel Institute
Peter W. Laird: Department of Epigenetics, Van Andel Institute

DOI: https://doi.org/10.1038/s41467-022-34268-8
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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DNA methylation loss has been observed in aging tissues and cancers for decades. Researchers from Van Andel Institute have now provided experimental evidence that this process is directly driven by cell division.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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