Beilstein Journal of Organic Chemistry (Nov 2012)

Engineering of indole-based tethered biheterocyclic alkaloid meridianin into β-carboline-derived tetracyclic polyheterocycles via amino functionalization/6-endo cationic π-cyclization

  • Piyush K. Agarwal,
  • Meena D. Dathi,
  • Mohammad Saifuddin,
  • Bijoy Kundu

DOI
https://doi.org/10.3762/bjoc.8.220
Journal volume & issue
Vol. 8, no. 1
pp. 1901 – 1908

Abstract

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A mild, efficient and versatile method has been developed for the construction of a functionalized natural product, meridianin, and its post conversion to pyrimido-β-carboline by cationic π- cyclization. The strategy involves the introduction of an amino group at the C-5 of the pyrimidine ring and utilizing the nucleophilictiy of the C-2 in the indole ring to facilitate cationic π-cyclization.

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