Nature Communications (May 2021)

Evidence from oyster suggests an ancient role for Pdx in regulating insulin gene expression in animals

  • Fei Xu,
  • Ferdinand Marlétaz,
  • Daria Gavriouchkina,
  • Xiao Liu,
  • Tatjana Sauka-Spengler,
  • Guofan Zhang,
  • Peter W. H. Holland

DOI
https://doi.org/10.1038/s41467-021-23216-7
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

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In vertebrates insulin is a direct transcriptional target of Pdx: the same is true in Pacific oysters and the authors show insulin-related gene, cgILP, is co-expressed with cgPdx in oyster digestive tissue, showing this gene interaction dates back to the origin of Bilateria.