Frontiers in Medicine (Jan 2022)

Anti-citrullinated Protein Antibody Generation, Pathogenesis, Clinical Application, and Prospects

  • Jiaxi Liu,
  • Jinfang Gao,
  • Zewen Wu,
  • Liangyu Mi,
  • Na Li,
  • Yajing Wang,
  • Xinyue Peng,
  • Ke Xu,
  • Fengping Wu,
  • Liyun Zhang

DOI
https://doi.org/10.3389/fmed.2021.802934
Journal volume & issue
Vol. 8

Abstract

Read online

Anti-citrullinated protein antibodies (ACPAs) are autoantibodies commonly observed in patients with rheumatoid arthritis (RA). Currently, most of the mechanisms of ACPA formation and bone destruction are well-understood, however, some unknown mechanisms still exist. There have been many new advances in ACPA-related clinical applications and targeted therapies. However, the existence of different ACPA subtypes is a limitation of targeted therapy. Herein, we present an overview of the process of ACPA generation, the underlying pathogenesis, and relevant clinical application and prospects.

Keywords