Nature Communications (Apr 2023)

In situ orderly self-assembly strategy affording NIR-II-J-aggregates for in vivo imaging and surgical navigation

  • Zhe Li,
  • Ping-Zhao Liang,
  • Li Xu,
  • Xing-Xing Zhang,
  • Ke Li,
  • Qian Wu,
  • Xiao-Feng Lou,
  • Tian-Bing Ren,
  • Lin Yuan,
  • Xiao-Bing Zhang

DOI
https://doi.org/10.1038/s41467-023-37586-7
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 14

Abstract

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J-aggregation, is an effective strategy to extend the wavelength of organic NIR-II fluorescence dyes but weak intermolecular interactions often lead to decomposition of the aggregates in biological environment. Here, the authors demonstrate a series of activatable quinazoline derivatives which can self-assemble in vivo into highly stable NIR-IIJ-aggregates.