Traditional and Integrative Medicine (Mar 2017)
The effect of Boldenone and Aerobic Training with Jujube Extract and Gallic Acid on Glutathione Peroxidase and Catalase in Heart Tissue of Male Wistar Rats
Abstract
The aim of this study was to investigate the effect of boldenone and aerobic training with Jujube extract and Gallic acid on glutathione peroxidase and catalase in heart tissue of male Wistar rats. Thus, 42 male Wistar rats aged 8-12 weeks (weight 195±7.94g) were randomly divided into 7 groups: control, boldenone (5mg/kg), jujube (Ziziphus jujuba) extract + boldenone, Gallic acid + boldenone, endurance training + boldenone, endurance training + Ziziphus jujuba extract + boldenone, and endurance training + Gallic acid + boldenone. Endurance training protocol was performed 5 days a week for 8 weeks, each session 60 minutes at 25 to 30 meters per minute. Injection once a week, on an appointed day, and in the hamstring was conducted in depth. After anesthesia, autopsy was performed and the cardiac tissue isolated. Data were analyzed using t-test, one way ANOVA and Scheffe post hoc at the P<0.05. The results showed that there was a significant differences between catalase in the various groups (P=0.000). Catalase expression in boldenone + training + Gallic acid increased significantly compared to the boldenone (P=0.000) and control (P=0.000) group. Also, there was a significant differences between glutathione peroxidase in the various groups (P=0.000). Glutathione peroxidase expression significantly increased in boldenone + training + jujube compared to the boldenone (P=0.000) and control (P=0.000) group. According to the findings, it seems that boldenone injected with jujube extract /Gallic acid and performing endurance training for 8 weeks have beneficial effects on antioxidant system.
