Exposure to Zearalenone Leads to Metabolic Disruption and Changes in Circulating Adipokines Concentrations in Pigs
Veronika Nagl,
Bertrand Grenier,
Philippe Pinton,
Ursula Ruczizka,
Maximiliane Dippel,
Moritz Bünger,
Isabelle P. Oswald,
Laura Soler
Affiliations
Veronika Nagl
BIOMIN Research Center, BIOMIN Holding GmbH, Technopark 1, 3430 Tulln, Austria
Bertrand Grenier
BIOMIN Research Center, BIOMIN Holding GmbH, Technopark 1, 3430 Tulln, Austria
Philippe Pinton
Toxalim (Research Centre in Food Toxicology), INRAE, ENVT, INP-Purpan, University of Toulouse, UPS, 31027 Toulouse, France
Ursula Ruczizka
University Clinic for Swine, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210 Vienna, Austria
Maximiliane Dippel
University Clinic for Swine, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210 Vienna, Austria
Moritz Bünger
University Clinic for Swine, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210 Vienna, Austria
Isabelle P. Oswald
Toxalim (Research Centre in Food Toxicology), INRAE, ENVT, INP-Purpan, University of Toulouse, UPS, 31027 Toulouse, France
Laura Soler
Toxalim (Research Centre in Food Toxicology), INRAE, ENVT, INP-Purpan, University of Toulouse, UPS, 31027 Toulouse, France
Zearalenone (ZEN) is a mycotoxin classified as an endocrine disruptor. Many endocrine disruptors are also metabolic disruptors able to modulate energy balance and inflammatory processes in a process often involving a family of protein hormones known as adipokines. The aim of our study was to elucidate the role of ZEN as metabolic disruptor in pigs by investigating the changes in energy balance and adipokines levels in response to different treatment diets. To this end, weaned piglets (n = 10/group) were exposed to either basal feed or feed contaminated with 680 and 1620 µg/kg ZEN for 28 days. Serum samples collected at days 7 and 21 were subjected to biochemistry analysis, followed by determination of adipokine levels using a combined approach of protein array and ELISA. Results indicate that ZEN has an impact on lipid and glucose metabolism that was different depending on the dose and time of exposure. In agreement with these changes, ZEN altered circulating adipokines concentrations, inducing significant changes in adiponectin, resistin, and fetuin B. Our results suggest that ZEN may function as a natural metabolism-disrupting chemical.
