Nature Communications (Jan 2021)

Transcription shapes genome-wide histone acetylation patterns

  • Benjamin J. E. Martin,
  • Julie Brind’Amour,
  • Anastasia Kuzmin,
  • Kristoffer N. Jensen,
  • Zhen Cheng Liu,
  • Matthew Lorincz,
  • LeAnn J. Howe

DOI
https://doi.org/10.1038/s41467-020-20543-z
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 9

Abstract

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Histone acetylation is a ubiquitous hallmark of transcription. Here the authors provide evidence that the majority of histone acetylation is dependent on transcription, specifically due to the requirement of RNAPII for the recruitment and activity of histone acetyltransferases.