4D Printing: The Development of Responsive Materials Using 3D-Printing Technology
Pablo Edmundo Antezana,
Sofia Municoy,
Gabriel Ostapchuk,
Paolo Nicolás Catalano,
John G. Hardy,
Pablo Andrés Evelson,
Gorka Orive,
Martin Federico Desimone
Affiliations
Pablo Edmundo Antezana
Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de la Química y Metabolismo del Fármaco (IQUIMEFA), Facultad de Farmacia y Bioquímica Junín 956, Piso 3, Buenos Aires 1113, Argentina
Sofia Municoy
Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de la Química y Metabolismo del Fármaco (IQUIMEFA), Facultad de Farmacia y Bioquímica Junín 956, Piso 3, Buenos Aires 1113, Argentina
Gabriel Ostapchuk
Instituto de Nanociencia y Nanotecnología (CNEA-CONICET), Nodo Constituyentes, Av. Gral. Paz 1499 (B1650KNA), San Martín, Buenos Aires 8400, Argentina
Paolo Nicolás Catalano
Instituto de Nanociencia y Nanotecnología (CNEA-CONICET), Nodo Constituyentes, Av. Gral. Paz 1499 (B1650KNA), San Martín, Buenos Aires 8400, Argentina
John G. Hardy
Materials Science Institute, Lancaster University, Lancaster LA1 4YB, UK
Pablo Andrés Evelson
Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Bioquímica y Medicina Molecular (IBIMOL), Facultad de Farmacia y Bioquímica, Buenos Aires 1428, Argentina
Gorka Orive
NanoBioCel Research Group, School of Pharmacy, University of the Basque Country (UPV/EHU), 01006 Vitoria-Gasteiz, Spain
Martin Federico Desimone
Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de la Química y Metabolismo del Fármaco (IQUIMEFA), Facultad de Farmacia y Bioquímica Junín 956, Piso 3, Buenos Aires 1113, Argentina
Additive manufacturing, widely known as 3D printing, has revolutionized the production of biomaterials. While conventional 3D-printed structures are perceived as static, 4D printing introduces the ability to fabricate materials capable of self-transforming their configuration or function over time in response to external stimuli such as temperature, light, or electric field. This transformative technology has garnered significant attention in the field of biomedical engineering due to its potential to address limitations associated with traditional therapies. Here, we delve into an in-depth review of 4D-printing systems, exploring their diverse biomedical applications and meticulously evaluating their advantages and disadvantages. We emphasize the novelty of this review paper by highlighting the latest advancements and emerging trends in 4D-printing technology, particularly in the context of biomedical applications.