Racemic N-methyl-4-[2-(methylsulfanyl)pyrimidin-4-yl]-1-(tetrahydrofuran-3-yl)-1H-pyrazol-5-amine

Abstract

The title compound, C13H17N5OS, was obtained by cycloaddition of 2-[2-(methylsulfanyl)pyrimidin-4-yl]-3-oxopropanenitrile with (tetrahydrofuran-3-yl)hydrazine dihydrochloride and subsequent N-methylation of 4-[2-(methylsulfanyl)pyrimidin-4-yl]-1-(tetrahydrofuran-2-yl)-1H-pyrazol-5-amine with methyl iodide. The two molecules in the asymmetric unit have opposite absolute configurations and are related by a noncrystallographic inversion center. Both feature intramolecular N—H...N hydrogen bonds. The geometry of the molecules is similar to that observed in the structure of a single enantiomer of the title compound.