Alzheimer’s Research & Therapy (Aug 2022)
Italian adaptation of the Uniform Data Set Neuropsychological Test Battery (I-UDSNB 1.0): development and normative data
- Francesca Conca,
- Valentina Esposito,
- Francesco Rundo,
- Davide Quaranta,
- Cristina Muscio,
- Rosa Manenti,
- Giulia Caruso,
- Ugo Lucca,
- Alessia Antonella Galbussera,
- Sonia Di Tella,
- Francesca Baglio,
- Federica L’Abbate,
- Elisa Canu,
- Valentina Catania,
- Massimo Filippi,
- Giulia Mattavelli,
- Barbara Poletti,
- Vincenzo Silani,
- Raffaele Lodi,
- Maddalena De Matteis,
- Michelangelo Stanzani Maserati,
- Andrea Arighi,
- Emanuela Rotondo,
- Antonio Tanzilli,
- Andrea Pace,
- Federica Garramone,
- Carlo Cavaliere,
- Matteo Pardini,
- Cristiano Rizzetto,
- Sandro Sorbi,
- Roberta Perri,
- Pietro Tiraboschi,
- Nicola Canessa,
- Maria Cotelli,
- Raffaele Ferri,
- Sandra Weintraub,
- Camillo Marra,
- Fabrizio Tagliavini,
- Eleonora Catricalà,
- Stefano Francesco Cappa
Affiliations
- Francesca Conca
- IRCCS Mondino Foundation
- Valentina Esposito
- IRCCS Mondino Foundation
- Francesco Rundo
- Department of Neurology IC, Oasi Research Institute – IRCCS
- Davide Quaranta
- Neurology Unit, Fondazione Policlinico Universitario “A. Gemelli” IRCCS
- Cristina Muscio
- Fondazione IRCCS Istituto Neurologico Carlo Besta
- Rosa Manenti
- IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli
- Giulia Caruso
- Laboratory of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation
- Ugo Lucca
- Laboratory of Geriatric Neuropsychiatry, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS
- Alessia Antonella Galbussera
- Laboratory of Geriatric Neuropsychiatry, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS
- Sonia Di Tella
- IRCCS Fondazione Don Carlo Gnocchi, ONLUS
- Francesca Baglio
- IRCCS Fondazione Don Carlo Gnocchi, ONLUS
- Federica L’Abbate
- Neurology Unit, Fondazione Policlinico Universitario “A. Gemelli” IRCCS
- Elisa Canu
- Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute
- Valentina Catania
- Unit of Psychology I.C., Oasi Research Institute–IRCCS
- Massimo Filippi
- Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute
- Giulia Mattavelli
- IUSS Cognitive Neuroscience (ICON) Center, Scuola Universitaria Superiore IUSS
- Barbara Poletti
- Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano
- Vincenzo Silani
- Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano
- Raffaele Lodi
- IRCCS Istituto delle Scienze Neurologiche di Bologna
- Maddalena De Matteis
- IRCCS Istituto delle Scienze Neurologiche di Bologna
- Michelangelo Stanzani Maserati
- IRCCS Istituto delle Scienze Neurologiche di Bologna
- Andrea Arighi
- Fondazione IRCSS ca’ Granda, Ospedale Policlinico
- Emanuela Rotondo
- Fondazione IRCSS ca’ Granda, Ospedale Policlinico
- Antonio Tanzilli
- Neuro-Oncology Unit, IRCCS Regina Elena National Cancer Institute
- Andrea Pace
- Neuro-Oncology Unit, IRCCS Regina Elena National Cancer Institute
- Federica Garramone
- IRCCS Synlab SDN of Naples
- Carlo Cavaliere
- IRCCS Synlab SDN of Naples
- Matteo Pardini
- IRCCS Ospedale Policlinico San Martino
- Cristiano Rizzetto
- IRCCS Ospedale Policlinico San Martino
- Sandro Sorbi
- IRCCS Fondazione Don Carlo Gnocchi, ONLUS
- Roberta Perri
- Laboratory of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation
- Pietro Tiraboschi
- Fondazione IRCCS Istituto Neurologico Carlo Besta
- Nicola Canessa
- IUSS Cognitive Neuroscience (ICON) Center, Scuola Universitaria Superiore IUSS
- Maria Cotelli
- IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli
- Raffaele Ferri
- Department of Neurology IC, Oasi Research Institute – IRCCS
- Sandra Weintraub
- Mesulam Center for Cognitive Neurology and Alzheimer’s Disease and Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Department of Neurology, Northwestern University
- Camillo Marra
- Neurology Unit, Fondazione Policlinico Universitario “A. Gemelli” IRCCS
- Fabrizio Tagliavini
- Fondazione IRCCS Istituto Neurologico Carlo Besta
- Eleonora Catricalà
- IRCCS Mondino Foundation
- Stefano Francesco Cappa
- IRCCS Mondino Foundation
- DOI
- https://doi.org/10.1186/s13195-022-01056-x
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 11
Abstract
Abstract Background Neuropsychological testing plays a cardinal role in the diagnosis and monitoring of Alzheimer’s disease. A major concern is represented by the heterogeneity of the neuropsychological batteries currently adopted in memory clinics and healthcare centers. The current study aimed to solve this issue. Methods Following the initiative of the University of Washington’s National Alzheimer’s Coordinating Center (NACC), we presented the Italian adaptation of the Neuropsychological Test Battery of the Uniform Data Set (I-UDSNB). We collected data from 433 healthy Italian individuals and employed regression models to evaluate the impact of demographic variables on the performance, deriving the reference norms. Results Higher education and lower age were associated with a better performance in the majority of tests, while sex affected only fluency tests and Digit Span Forward. Conclusions The I-UDSNB offers a valuable and harmonized tool for neuropsychological testing in Italy, to be used in clinical and research settings.
Keywords
