Nature Communications (Aug 2021)
Ten-eleven translocation 1 mediated-DNA hydroxymethylation is required for myelination and remyelination in the mouse brain
- Ming Zhang,
- Jian Wang,
- Kaixiang Zhang,
- Guozhen Lu,
- Yuming Liu,
- Keke Ren,
- Wenting Wang,
- Dazhuan Xin,
- Lingli Xu,
- Honghui Mao,
- Junlin Xing,
- Xingchun Gao,
- Weilin Jin,
- Kalen Berry,
- Katsuhiko Mikoshiba,
- Shengxi Wu,
- Q. Richard Lu,
- Xianghui Zhao
Affiliations
- Ming Zhang
- Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University
- Jian Wang
- Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University
- Kaixiang Zhang
- Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University
- Guozhen Lu
- Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University
- Yuming Liu
- Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University
- Keke Ren
- Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University
- Wenting Wang
- Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University
- Dazhuan Xin
- Division of Experimental Hematology and Cancer Biology, Brain Tumor Center, Cincinnati Children’s Hospital Medical Center
- Lingli Xu
- Center for molecular medicine, Pediatric Research Institute, Children’s Hospital of Fudan University
- Honghui Mao
- Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University
- Junlin Xing
- Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University
- Xingchun Gao
- Shaanxi Key Laboratory of Brain Disorders, Xi’an Medical University
- Weilin Jin
- Institute of Cancer Neuroscience, Medical Frontier Innovation Research Center, The First Hospital of Lanzhou University
- Kalen Berry
- Division of Experimental Hematology and Cancer Biology, Brain Tumor Center, Cincinnati Children’s Hospital Medical Center
- Katsuhiko Mikoshiba
- Faculty of Science, Toho University
- Shengxi Wu
- Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University
- Q. Richard Lu
- Division of Experimental Hematology and Cancer Biology, Brain Tumor Center, Cincinnati Children’s Hospital Medical Center
- Xianghui Zhao
- Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University
- DOI
- https://doi.org/10.1038/s41467-021-25353-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 21
Abstract
Myelin formation is regulated by epigenetic mechanisms and ensures proper neuronal function during development and after demyelination. Here, the authors show that TET1, a DNA hydroxymethylase, regulates myelination during development and remyelination in mice.
