Nature Communications (Mar 2019)
Structure mapping of dengue and Zika viruses reveals functional long-range interactions
- Roland G. Huber,
- Xin Ni Lim,
- Wy Ching Ng,
- Adelene Y. L. Sim,
- Hui Xian Poh,
- Yang Shen,
- Su Ying Lim,
- Karin B. Sundstrom,
- Xuyang Sun,
- Jong Ghut Aw,
- Horng Khit Too,
- Peng Hee Boey,
- Andreas Wilm,
- Tanu Chawla,
- Milly M. Choy,
- Lu Jiang,
- Paola Florez de Sessions,
- Xian Jun Loh,
- Sylvie Alonso,
- Martin Hibberd,
- Niranjan Nagarajan,
- Eng Eong Ooi,
- Peter J. Bond,
- October M. Sessions,
- Yue Wan
Affiliations
- Roland G. Huber
- Bioinformatics Institute (A*STAR)
- Xin Ni Lim
- Stem Cell and Regenerative Biology, Genome Institute of Singapore
- Wy Ching Ng
- Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School
- Adelene Y. L. Sim
- Bioinformatics Institute (A*STAR)
- Hui Xian Poh
- Stem Cell and Regenerative Biology, Genome Institute of Singapore
- Yang Shen
- Computational Biology, Genome Institute of Singapore
- Su Ying Lim
- Stem Cell and Regenerative Biology, Genome Institute of Singapore
- Karin B. Sundstrom
- Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School
- Xuyang Sun
- Department of Neurology, National Neuroscience Institute
- Jong Ghut Aw
- Stem Cell and Regenerative Biology, Genome Institute of Singapore
- Horng Khit Too
- Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore
- Peng Hee Boey
- Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore
- Andreas Wilm
- Computational Biology, Genome Institute of Singapore
- Tanu Chawla
- Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School
- Milly M. Choy
- Infectious Diseases, Genome Institute of Singapore
- Lu Jiang
- Institute of Materials Research and Engineering (IMRE), A*STAR
- Paola Florez de Sessions
- GERMS Platform, Genome Institute of Singapore
- Xian Jun Loh
- Institute of Materials Research and Engineering (IMRE), A*STAR
- Sylvie Alonso
- Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore
- Martin Hibberd
- Infectious Diseases, Genome Institute of Singapore
- Niranjan Nagarajan
- Computational Biology, Genome Institute of Singapore
- Eng Eong Ooi
- Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School
- Peter J. Bond
- Bioinformatics Institute (A*STAR)
- October M. Sessions
- Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School
- Yue Wan
- Stem Cell and Regenerative Biology, Genome Institute of Singapore
- DOI
- https://doi.org/10.1038/s41467-019-09391-8
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Here, the authors provide detailed analyses of viral RNA structure in virions and in infected cells for four dengue virus serotypes and four Zika virus strains, and identify conserved structures that are important for virus replication.
