Structural basis for safe and efficient energy conversion in a respiratory supercomplex

Wei-Chun Kao; Claire Ortmann de Percin Northumberland; Tat Cheung Cheng; Julio Ortiz; Alexandre Durand; Ottilie von Loeffelholz; Oliver Schilling; Martin L. Biniossek; Bruno P. Klaholz; Carola Hunte

doi:10.1038/s41467-022-28179-x

Nature Communications (Jan 2022)

Structural basis for safe and efficient energy conversion in a respiratory supercomplex

Wei-Chun Kao,
Claire Ortmann de Percin Northumberland,
Tat Cheung Cheng,
Julio Ortiz,
Alexandre Durand,
Ottilie von Loeffelholz,
Oliver Schilling,
Martin L. Biniossek,
Bruno P. Klaholz,
Carola Hunte

Affiliations

Wei-Chun Kao: Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg
Claire Ortmann de Percin Northumberland: Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg
Tat Cheung Cheng: Centre for Integrative Biology (CBI), Department of Integrated Structural Biology, IGBMC, CNRS, Inserm, Université de Strasbourg
Julio Ortiz: Centre for Integrative Biology (CBI), Department of Integrated Structural Biology, IGBMC, CNRS, Inserm, Université de Strasbourg
Alexandre Durand: Centre for Integrative Biology (CBI), Department of Integrated Structural Biology, IGBMC, CNRS, Inserm, Université de Strasbourg
Ottilie von Loeffelholz: Centre for Integrative Biology (CBI), Department of Integrated Structural Biology, IGBMC, CNRS, Inserm, Université de Strasbourg
Oliver Schilling: Institute of Surgical Pathology, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg
Martin L. Biniossek: Institute of Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg
Bruno P. Klaholz: Centre for Integrative Biology (CBI), Department of Integrated Structural Biology, IGBMC, CNRS, Inserm, Université de Strasbourg
Carola Hunte: Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg

DOI: https://doi.org/10.1038/s41467-022-28179-x
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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Aerobic energy metabolism is driven by proton-pumping respiratory supercomplexes. The study reports the structural basis for energy conversion in such supercomplex. It may aid metabolic engineering and drug design against diphtheria and tuberculosis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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