Frontiers in Pharmacology (Feb 2022)
Efficient Synthesis of 2,3′-Spirobi (Indolin)-2′-Ones and Preliminary Evaluation of Their Damage to Mitochondria in HeLa Cells
- Huajie Li,
- Huajie Li,
- Zhenjie Yu,
- Zhenjie Yu,
- Haoyi Sun,
- Haoyi Sun,
- Bo Liu,
- Bo Liu,
- Xin Wang,
- Xin Wang,
- Zhe Shao,
- Zhe Shao,
- Meiling Wang,
- Meiling Wang,
- Weilin Xie,
- Weilin Xie,
- Xingang Yao,
- Qingqiang Yao,
- Qingqiang Yao,
- Ying Zhi,
- Ying Zhi
Affiliations
- Huajie Li
- School of Pharmacy and Pharmaceutical Sciences, Shandong First Medical University, Jinan, China
- Huajie Li
- Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, China
- Zhenjie Yu
- School of Pharmacy and Pharmaceutical Sciences, Shandong First Medical University, Jinan, China
- Zhenjie Yu
- Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, China
- Haoyi Sun
- School of Pharmacy and Pharmaceutical Sciences, Shandong First Medical University, Jinan, China
- Haoyi Sun
- Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, China
- Bo Liu
- School of Pharmacy and Pharmaceutical Sciences, Shandong First Medical University, Jinan, China
- Bo Liu
- Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, China
- Xin Wang
- School of Pharmacy and Pharmaceutical Sciences, Shandong First Medical University, Jinan, China
- Xin Wang
- Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, China
- Zhe Shao
- School of Pharmacy and Pharmaceutical Sciences, Shandong First Medical University, Jinan, China
- Zhe Shao
- Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, China
- Meiling Wang
- School of Pharmacy and Pharmaceutical Sciences, Shandong First Medical University, Jinan, China
- Meiling Wang
- Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, China
- Weilin Xie
- School of Pharmacy and Pharmaceutical Sciences, Shandong First Medical University, Jinan, China
- Weilin Xie
- Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, China
- Xingang Yao
- School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
- Qingqiang Yao
- School of Pharmacy and Pharmaceutical Sciences, Shandong First Medical University, Jinan, China
- Qingqiang Yao
- Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, China
- Ying Zhi
- School of Pharmacy and Pharmaceutical Sciences, Shandong First Medical University, Jinan, China
- Ying Zhi
- Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, China
- DOI
- https://doi.org/10.3389/fphar.2021.821518
- Journal volume & issue
-
Vol. 12
Abstract
A novel formal (4 + 1) annulation between N-(o-chloromethyl)aryl amides and 3-chlorooxindoles through in situ generated aza-ortho-QMs with 3-chlorooxindoles is reported for the synthesis of a series of 2,3′-spirobi (indolin)-2′-ones in high yields. Under structured illumination microscopy, compound 3a is found to change the mitochondrial morphology and induce mitophagy pathway, which might then trigger mitophagy in cancer cells.
Keywords
