Remote light-controlled intracellular target recognition by photochromic fluorescent glycoprobes

Junji Zhang; Youxin Fu; Hai-Hao Han; Yi Zang; Jia Li; Xiao-Peng He; Ben L. Feringa; He Tian

doi:10.1038/s41467-017-01137-8

Nature Communications (Oct 2017)

Remote light-controlled intracellular target recognition by photochromic fluorescent glycoprobes

Junji Zhang,
Youxin Fu,
Hai-Hao Han,
Yi Zang,
Jia Li,
Xiao-Peng He,
Ben L. Feringa,
He Tian

Affiliations

Junji Zhang: Key Laboratory for Advanced Materials & Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology
Youxin Fu: Key Laboratory for Advanced Materials & Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology
Hai-Hao Han: Key Laboratory for Advanced Materials & Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology
Yi Zang: National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Jia Li: National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Xiao-Peng He: Key Laboratory for Advanced Materials & Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology
Ben L. Feringa: Centre for Systems Chemistry, Stratingh Institute for Chemistry and Zernike Institute for Advanced Materials, Faculty of Mathematics and Natural Sciences, University of Groningen
He Tian: Key Laboratory for Advanced Materials & Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology

DOI: https://doi.org/10.1038/s41467-017-01137-8
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 9

Abstract

Read online

Fluorescence sensing in biological environments is prone to background signal interference. Here the authors design a photochromic fluorescent glycoprobe for light-controlled photo-switchable cell imaging and photo-activated target recognition, resulting in an increased sensing precision.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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