Blockade of Glutamate Release by Botulinum Neurotoxin Type A in Humans: A Dermal Microdialysis Study

Larissa Bittencourt da Silva; Ali Karshenas; Flemming W Bach; Sten Rasmussen; Lars Arendt-Nielsen; Parisa Gazerani

doi:10.1155/2014/410415

Pain Research and Management (Jan 2014)

Blockade of Glutamate Release by Botulinum Neurotoxin Type A in Humans: A Dermal Microdialysis Study

Larissa Bittencourt da Silva,
Ali Karshenas,
Flemming W Bach,
Sten Rasmussen,
Lars Arendt-Nielsen,
Parisa Gazerani

Affiliations

Larissa Bittencourt da Silva: Center for Sensory-Motor Interaction, Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark
Ali Karshenas: Department of Neurology, Aalborg University Hospital, Aalborg, Denmark
Flemming W Bach: Department of Neurology, Aalborg University Hospital, Aalborg, Denmark
Sten Rasmussen: Orthopaedic Surgery Research Unit, Aalborg Hospital Science and Innovation Center, Aalborg University Hospital, Aalborg, Denmark
Lars Arendt-Nielsen: Center for Sensory-Motor Interaction, Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark
Parisa Gazerani: Center for Sensory-Motor Interaction, Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark

DOI: https://doi.org/10.1155/2014/410415
Journal volume & issue: Vol. 19, no. 3
pp. 126 – 132

Abstract

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BACKGROUND: The analgesic action of botulinum neurotoxin type A (BoNTA) has been linked to the blockade of peripheral release of neuropeptides and neurotransmitters in animal models; however, there is no direct evidence of this in humans.

Published in Pain Research and Management

ISSN: 1203-6765 (Print); 1918-1523 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Medicine (General)
Website: https://onlinelibrary.wiley.com/journal/7040

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