Epidemiology and clinical course of COVID-19 in Shanghai, China

Yinzhong Shen; Fang Zheng; Danfeng Sun; Yun Ling; Jun Chen; Feng Li; Tao Li; Zhiping Qian; Yuyi Zhang; Qingnian Xu; Li Liu; Qin Huang; Fei Shan; Lie Xu; Jun Wu; Zhaoqin Zhu; Zhigang Song; Shenyang Li; Yuxin Shi; Jianliang Zhang; Xueyun Wu; Joshua B. Mendelsohn; Tongyu Zhu; Hongzhou Lu

doi:10.1080/22221751.2020.1787103

Emerging Microbes and Infections (Jan 2020)

Epidemiology and clinical course of COVID-19 in Shanghai, China

Yinzhong Shen,
Fang Zheng,
Danfeng Sun,
Yun Ling,
Jun Chen,
Feng Li,
Tao Li,
Zhiping Qian,
Yuyi Zhang,
Qingnian Xu,
Li Liu,
Qin Huang,
Fei Shan,
Lie Xu,
Jun Wu,
Zhaoqin Zhu,
Zhigang Song,
Shenyang Li,
Yuxin Shi,
Jianliang Zhang,
Xueyun Wu,
Joshua B. Mendelsohn,
Tongyu Zhu,
Hongzhou Lu

Affiliations

Yinzhong Shen: Department of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of China
Fang Zheng: Department of Medical Affairs, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of China
Danfeng Sun: Department of Medical Affairs, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of China
Yun Ling: Department of Infection, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of China
Jun Chen: Department of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of China
Feng Li: Department of Respiratory Medicine, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of China
Tao Li: Department of Tuberculosis, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of China
Zhiping Qian: Department of Severe Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China
Yuyi Zhang: Department of Severe Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China
Qingnian Xu: Department of Traditional Chinese Medicine, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of China
Li Liu: Department of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of China
Qin Huang: Department of Infection, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of China
Fei Shan: Department of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of China
Lie Xu: Department of Medical Affairs, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of China
Jun Wu: Department of Medical Affairs, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of China
Zhaoqin Zhu: Clinical Laboratory, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of China
Zhigang Song: P3 Laboratory, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of China
Shenyang Li: Data Management Center, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of China
Yuxin Shi: Department of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of China
Jianliang Zhang: Department of Gastroenterology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of China
Xueyun Wu: Department of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of China
Joshua B. Mendelsohn: College of Health Professions, Pace University, New York, NY, USA
Tongyu Zhu: Department of Urology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of China
Hongzhou Lu: Department of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of China

DOI: https://doi.org/10.1080/22221751.2020.1787103
Journal volume & issue: Vol. 9, no. 1
pp. 1537 – 1545

Abstract

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ABSTRACTBackground: Novel coronavirus pneumonia (COVID-19) is prevalent around the world. We aimed to describe epidemiological features and clinical course in Shanghai.Methods: We retrospectively analysed 325 cases admitted at Shanghai Public Health Clinical Center, between January 20 and February 29, 2020.Results: 47.4% (154/325) had visited Wuhan within 2 weeks of illness onset. 57.2% occurred in 67 clusters; 40% were situated within 53 family clusters. 83.7% developed fever during the disease course. Median times from onset to first medical care, hospitalization and negative detection of nucleic acid by nasopharyngeal swab were 1, 4 and 8 days. Patients with mild disease using glucocorticoid tended to have longer viral shedding in blood and feces. At admission, 69.8% presented with lymphopenia and 38.8% had elevated D-dimers. Pneumonia was identified in 97.5% (314/322) of cases by chest CT scan. Severe-critical patients were 8% with a median time from onset to critical disease of 10.5 days. Half required oxygen therapy and 7.1% high-flow nasal oxygen. The case fatality rate was 0.92% with median time from onset to death of 16 days.Conclusion: COVID-19 cases in Shanghai were imported. Rapid identification, and effective control measures helped to contain the outbreak and prevent community transmission.

Published in Emerging Microbes and Infections

ISSN: 2222-1751 (Online)
Publisher: Taylor & Francis Group
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases; Science: Microbiology
Website: https://www.tandfonline.com/journals/temi

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