PROGNOSTIC AND DIAGNOSTIC SIGNIFICANCE OF THE CLARA CELL PROTEIN LEVEL IN BRONCHOPULMONARY DYSPLASIA IN PRETERM NEWBORNS

Abstract

Background. Bronchopulmonary dysplasia (BPD) is a polyetiological chronic disease of morphologically immature lungs that develops in premature newborns receiving oxygen and undergoing mechanical lung ventilation (MLV). The study of the severity and outcomes of bronchopulmonary dysplasia is one of the signifcant felds of modern research studies in pediatrics. The aim of our research was to determine Clara cell protein (CCP) levels in tracheal aspirate and blood serum in mechanically ventilated premature newborns with features of respiratory failure, who were subsequently diagnosed with BPD. Material and methods. Under our supervision, there were 34 preterm infants with respiratory disorders, who have been on mechanical ventilation for more than 1 week. The object of the study was serum and tracheal aspirate, sampling was performed twice on the 1st-2nd days and on the 10th-12th days. Results. In children who developed BPD, a low level of CCP in tracheal aspirate was noted. The level of CCP positively correlated with the diagnosis of BPD and negatively with the severity of the disease. Conclusions. Children with bronchopulmonary dysplasia on the 1st-2nd and 10th-12th days of life in TA and blood serum showed a low concentration of CCP (p <0.01) compared with the group of children without BPD.

Keywords

• newborns
• bronchopulmonary dysplasia
• clara cell protein
• biomarkers
• premature newborns