Novel Hydrogel-Advanced Modified Clay Nanocomposites as Possible Vehicles for Drug Delivery and Controlled Release
Raluca Ianchis,
Claudia M. Ninciuleanu,
Ioana C. Gifu,
Elvira Alexandrescu,
Raluca Somoghi,
Augusta R. Gabor,
Silviu Preda,
Cristina L. Nistor,
Sabina Nitu,
Cristian Petcu,
Madalina Icriverzi,
Paula E. Florian,
Anca M. Roseanu
Affiliations
Raluca Ianchis
National R-D Institute for Chemistry and Petrochemistry ICECHIM—Bucharest, Spl. Independentei 202, 6th district, P.O. Box 35/174, 060021 Bucharest, Romania
Claudia M. Ninciuleanu
National R-D Institute for Chemistry and Petrochemistry ICECHIM—Bucharest, Spl. Independentei 202, 6th district, P.O. Box 35/174, 060021 Bucharest, Romania
Ioana C. Gifu
National R-D Institute for Chemistry and Petrochemistry ICECHIM—Bucharest, Spl. Independentei 202, 6th district, P.O. Box 35/174, 060021 Bucharest, Romania
Elvira Alexandrescu
National R-D Institute for Chemistry and Petrochemistry ICECHIM—Bucharest, Spl. Independentei 202, 6th district, P.O. Box 35/174, 060021 Bucharest, Romania
Raluca Somoghi
National R-D Institute for Chemistry and Petrochemistry ICECHIM—Bucharest, Spl. Independentei 202, 6th district, P.O. Box 35/174, 060021 Bucharest, Romania
Augusta R. Gabor
National R-D Institute for Chemistry and Petrochemistry ICECHIM—Bucharest, Spl. Independentei 202, 6th district, P.O. Box 35/174, 060021 Bucharest, Romania
Silviu Preda
Institute of Physical Chemistry “Ilie Murgulescu”, Romanian Academy, Spl. Independentei 202, 6th district, P.O. Box 194, 060021 Bucharest, Romania
Cristina L. Nistor
National R-D Institute for Chemistry and Petrochemistry ICECHIM—Bucharest, Spl. Independentei 202, 6th district, P.O. Box 35/174, 060021 Bucharest, Romania
Sabina Nitu
National R-D Institute for Chemistry and Petrochemistry ICECHIM—Bucharest, Spl. Independentei 202, 6th district, P.O. Box 35/174, 060021 Bucharest, Romania
Cristian Petcu
National R-D Institute for Chemistry and Petrochemistry ICECHIM—Bucharest, Spl. Independentei 202, 6th district, P.O. Box 35/174, 060021 Bucharest, Romania
Madalina Icriverzi
Institute of Biochemistry of the Romanian Academy, Ligand-Receptor Interaction Department, Spl. Independentei 296, 060031 Bucharest 17, Romania
Paula E. Florian
Institute of Biochemistry of the Romanian Academy, Ligand-Receptor Interaction Department, Spl. Independentei 296, 060031 Bucharest 17, Romania
Anca M. Roseanu
Institute of Biochemistry of the Romanian Academy, Ligand-Receptor Interaction Department, Spl. Independentei 296, 060031 Bucharest 17, Romania
Present study refers to the synthesis of new advanced materials based on poly(methacrylic acid) (PMAA) with previously reported own advanced modified clays by edge covalent bonding. This will create the premises to obtain nanocomposite hydrogels with combined hydrophilic-hydrophobic behavior absolutely necessary for co-delivery of polar/nonpolar substances. For the synthesis, N,N’-methylenebisacrylamide was used as cross-linker and ammonium persulphate as initiator. As a consequence of the inclusion of clay into the polymer matrix and the intercalation of PMAA between the layers as well as the presence of hydrophobic interactions occurred between partners, the final hydrogel nanocomposites possessed greater swelling degrees, slower de-swelling process and enhanced mechanical properties depending on the clay type in comparison with pure hydrogel. In vitro MTS ([3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt]) colorimetric assay showed that direct exposure with PMMA-clay-based constructs did not affect cell viability and proliferation in time (24 and 48 h) on either normal or adenocarcinoma cell lines.
