Changes in lipid peroxidation and antioxidant system parameters in the liver of rats using mexidol in experimental obesity and bronchial asthma

Abstract

Summary. The problem of bronchial asthma (BA) prevention and treatment in combination with obesity can be solved only on the basis of a deep understanding of the biochemical and physiological mechanisms of two pathologies formation. Among the biochemical mechanisms underlying their development, the processes of free radical and peroxidation occupy a special place. The lungs and liver are the main target organs in the combination of ВA and obesity pathologies. However, despite the prevalence of these diseases, today's science has rather insignificant data on the state of LPO-AOS of the liver specifically in BA and obesity, and especially the effect of antioxidants on it, which requires study. The aim of the study – to determine the parameters of LPO-AOS in the liver of rats in an experimental model of obesity and ВA and the effect of Mexidol on them. Materials and Methods. The study included 20 white non-linear sexually mature rats. Experimental animals were divided into 4 groups: intact – control group (5 rats), group 1 – observation group on day 15 without Mexidol correction (5 rats), group 2 – observation group on day 26 without Mexidol correction (5 rats) and group 3 – observation group on day 26 after Mexidol correction experiment (5 rats). The content of malondialdehyde, conjugated diene, superoxide dismutase, catalase activity, and ceruloplasmin content were studied. Results. In experimental groups 1 and 2 the LPO parameters increased (p

Keywords

• bronchial asthma
• obesity
• lpo
• aos
• mexidol