TOMM34 serves as a candidate therapeutic target associated with immune cell infiltration in colon cancer

Zhigui Li; Hongzhao Yang; Jianbo Liu; Li Li; Xiaodong Wang

doi:10.3389/fonc.2023.947364

Frontiers in Oncology (Feb 2023)

TOMM34 serves as a candidate therapeutic target associated with immune cell infiltration in colon cancer

Zhigui Li,
Hongzhao Yang,
Jianbo Liu,
Li Li,
Xiaodong Wang

Affiliations

Zhigui Li: Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China
Hongzhao Yang: West China School of Medicine, Sichuan University, Chengdu, China
Jianbo Liu: Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China
Li Li: Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China
Xiaodong Wang: Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China

DOI: https://doi.org/10.3389/fonc.2023.947364
Journal volume & issue: Vol. 13

Abstract

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BackgroundColon cancer represents one of the most pervasive digestive malignancies worldwide. Translocase of the outer mitochondrial membrane 34 (TOMM34) is considered an oncogene and is implicated in tumor proliferation. However, the correlation between TOMM34 and immune cell infiltration in colon cancer has not been investigated.Materials and methodsBased on multiple open online databases, we performed integrated bioinformatics analysis of TOMM34 to evaluate the prognostic value of TOMM34 and its correlation with immune cell infiltration.ResultsTOMM34 gene and protein expression levels were elevated in tumor tissues compared with normal tissues. Survival analysis revealed that upregulation of TOMM34 was significantly associated with poorer survival time in colon cancer. High TOMM34 expression was dramatically related to low levels of B cells, CD8+ T cells, neutrophils, dendritic cells, PD-1, PD-L1 and CTLA-4.ConclusionsOur results confirmed that high expression of TOMM34 in tumor tissue correlates with immune cell infiltration and worse prognosis in colon cancer patients. TOMM34 may serve as a potential prognostic biomarker for colon cancer diagnosis and prognosis prediction.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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