Química Nova (Jan 2014)

In vitro effect of isoschaftoside isolated from Syngonium podophyllum on pig kidney Na+, K+-ATPase

  • Anne Caroline Candido Gomes,
  • Luzia da Silva Sampaio,
  • Paulo André da Silva,
  • Marcelo Einicker Lamas,
  • Cassia Mônica Sakuragui,
  • Cleber Bomfim Barreto Junior,
  • Naomi Kato Simas,
  • Ricardo Machado Kuster

DOI
https://doi.org/10.5935/0100-4042.20140257
Journal volume & issue
Vol. 37, no. 10
pp. 1606 – 1609

Abstract

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The present study aimed to investigate the in vitro effects of isoschaftoside isolated from Syngonium podophyllum on pig kidney Na+,K+-ATPase. The Na+, K+-ATPase activity was determined by colorimetric measurement of inorganic phosphate (Pi), resulting from ATP hydrolysis. Isoschaftoside significantly decreased the renal Na+, K+-ATPase activity at the highest concentration as well as at a lower concentration. Our work suggests that isoschaftoside is a promising compound for the treatment of hypertension.

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