A nitric-oxide driven chemotactic nanomotor for enhanced immunotherapy of glioblastoma

Huan Chen; Ting Li; Zhiyong Liu; Shuwan Tang; Jintao Tong; Yingfang Tao; Zinan Zhao; Nan Li; Chun Mao; Jian Shen; Mimi Wan

doi:10.1038/s41467-022-35709-0

Nature Communications (Feb 2023)

A nitric-oxide driven chemotactic nanomotor for enhanced immunotherapy of glioblastoma

Huan Chen,
Ting Li,
Zhiyong Liu,
Shuwan Tang,
Jintao Tong,
Yingfang Tao,
Zinan Zhao,
Nan Li,
Chun Mao,
Jian Shen,
Mimi Wan

Affiliations

Huan Chen: National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University
Ting Li: National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University
Zhiyong Liu: National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University
Shuwan Tang: National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University
Jintao Tong: College of Chemistry and Molecular Engineering, Peking University
Yingfang Tao: National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University
Zinan Zhao: National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University
Nan Li: National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University
Chun Mao: National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University
Jian Shen: National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University
Mimi Wan: National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University

DOI: https://doi.org/10.1038/s41467-022-35709-0
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 21

Abstract

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The blood-brain barrier represents a hurdle for the delivery of therapeutics in brain tumor tissues. Here the authors describe the design of a nitric oxide-driven nanomotor loaded with the glycolysis inhibitor lonidamine, breaking through the blood-brain barrier and eliciting anti-tumor immune responses in preclinical models of glioblastoma.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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