Changes in immunocompetent guinea pigs immunizing with Francisella Tularensislipopoly-saccharide

Abstract

Influence of Francisella tularensis lipopolysaccharide preparations on morphological changes in immunocompetent experimental animals was studied by subcutaneous introduction using survey microscopy and morphometric methods. Low expressed activation of B- and T-dependent bands in immunocompetent organs was determined. Proliferation of antigen-presented cells at early stages of investigation indicates the cell immunity activation. Pathomorphological alterations caused by lipopolysaccharide inoculation are homogeneous and benignant.

Keywords

• francisella tularensis lipopolysaccharide
• immunocompetent organ
• morphometry
• microscopy