Cancer Management and Research (Sep 2021)
HNRNPC Promotes Proliferation, Metastasis and Predicts Prognosis in Prostate Cancer
Abstract
Shiyu Wang,1,2 Guoxiong Xu,3 Fan Chao,1,2 Cong Zhang,1,2 Dunsheng Han,1,2 Gang Chen1,2 1Department of Urology, Jinshan Hospital, Fudan University, Shanghai, 201508, People’s Republic of China; 2Department of Surgery, Shanghai Medical College, Fudan University, Shanghai, 200032, People’s Republic of China; 3Research Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai, 201508, People’s Republic of ChinaCorrespondence: Gang ChenDepartment of Urology, Jinshan Hospital, Fudan University, Shanghai, 201508, People’s Republic of ChinaTel +86-21-34189990-5516Fax +86-21-67226966Email [email protected]: The incidence of prostate cancer remains high worldwide, while exploring new therapeutic targets for prostate cancer is essential. Heterogeneous nuclear ribonucleoproteins have been proved to regulate tumorigeneses in various cancers. This study aimed to explore the role of HNRNPC in prostate cancer progression.Methods: HNRNPC expression and its correlation with clinical features and immune infiltration were analyzed by bioinformatics analysis. The effects of HNRNPC on prostate cell proliferation, migration, and invasion were accessed by EdU, colony formation, transwell, and wound-healing assays.Results: The expression level of HNRNPC was significantly increased in prostate cancer tissues and was correlated with the T stage, N stage, Gleason score, PSA level, residual tumors, overall survival, disease-specific survival, and progression-free interval of prostate cancer patients. Silencing HNRNPC inhibited the proliferation and metastasis of prostate cancer cells. The expression of HNRNPC was negatively correlated with the infiltration level of most immune cells in prostate cancer. Mechanistically, HNRNPC may function through regulating gene expression at the posttranscriptional level.Conclusion: HNRNPC could be a potential marker for the treatment and prognosis prediction of prostate cancer.Keywords: HNRNPC, prostate cancer, proliferation, metastasis, immune infiltration
