Multivariate chemogenomic screening prioritizes new macrofilaricidal leads

Nicolas J. Wheeler; Kaetlyn T. Ryan; Kendra J. Gallo; Clair R. Henthorn; Spencer S. Ericksen; John D. Chan; Mostafa Zamanian

doi:10.1038/s42003-023-04435-8

Communications Biology (Jan 2023)

Multivariate chemogenomic screening prioritizes new macrofilaricidal leads

Nicolas J. Wheeler,
Kaetlyn T. Ryan,
Kendra J. Gallo,
Clair R. Henthorn,
Spencer S. Ericksen,
John D. Chan,
Mostafa Zamanian

Affiliations

Nicolas J. Wheeler: Department of Pathobiological Sciences, University of Wisconsin-Madison
Kaetlyn T. Ryan: Department of Pathobiological Sciences, University of Wisconsin-Madison
Kendra J. Gallo: Department of Pathobiological Sciences, University of Wisconsin-Madison
Clair R. Henthorn: Department of Pathobiological Sciences, University of Wisconsin-Madison
Spencer S. Ericksen: Small Molecule Screening Facility, Drug Development Core, UW-Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin-Madison
John D. Chan: Department of Pathobiological Sciences, University of Wisconsin-Madison
Mostafa Zamanian: Department of Pathobiological Sciences, University of Wisconsin-Madison

DOI: https://doi.org/10.1038/s42003-023-04435-8
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 15

Abstract

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A comprehensive optimization of phenotypic and computational screening strategy for antifilarial drug and target discovery identifies compounds with stage, species, and/or sex-specific activity, some with submicromolar potency.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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