Nature Communications (Nov 2022)

Mitochondrial Fission Process 1 controls inner membrane integrity and protects against heart failure

  • Erminia Donnarumma,
  • Michael Kohlhaas,
  • Elodie Vimont,
  • Etienne Kornobis,
  • Thibault Chaze,
  • Quentin Giai Gianetto,
  • Mariette Matondo,
  • Maryse Moya-Nilges,
  • Christoph Maack,
  • Timothy Wai

DOI
https://doi.org/10.1038/s41467-022-34316-3
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 24

Abstract

Read online

Mitochondria power the beating heart. Here, Donnarumma et al. show that loss of the inner mitochondrial membrane protein MTFP1 in cardiomyocytes reduces bioenergetic efficiency and cell death resistance leading to heart failure in mice.