Carveoylphenols and Their Antifungal Potential against Pathogenic Yeasts
Iván Montenegro,
Marco Mellado,
Alessandra Russo,
Bastian Said,
Ximena Besoain,
Patricio Godoy,
Enrique Werner,
Nelson Caro,
Alejandro Madrid
Affiliations
Iván Montenegro
Escuela de Obstetricia y Puericultura, Facultad de medicina, Universidad de Valparaíso, Angamos 655, Reñaca, Viña del Mar 2520000, Chile
Marco Mellado
Instituto de Química, Facultad de Ciencias, Pontificia Universidad Católica de Valparaíso, Av. Universidad #330, Curauma, Valparaíso 2340000, Chile
Alessandra Russo
Department of Drug Sciences, University of Catania, Via S. Sofia 64, 95125 Catania, Italy
Bastian Said
Departamento de Química, Universidad Técnica Federico Santa María, Av. Santa María 6400, Vitacura 7630000, Santiago, Chile
Ximena Besoain
Escuela de Agronomía Pontificia Universidad Católica de Valparaíso, Quillota, SanFrancisco s/n La Palma, Quillota 2260000, Chile
Patricio Godoy
Instituto de Microbiología Clínica, Facultad de Medicina, Universidad Austral de Chile, Los Laureles s/n, Isla Teja, Valdivia 5090000, Chile
Enrique Werner
Departamento de Ciencias Básicas, Campus Fernando May, Universidad del Bío-Bío, Avda. Andrés Bello 720, casilla 447, Chillán 3780000, Chile
Nelson Caro
Centro de Investigación Australbiotech, Universidad Santo Tomás, Avda. Ejército 146, Santiago 8320000, Chile
Alejandro Madrid
Laboratorio de Productos Naturales y Síntesis Orgánica (LPNSO), Departamento de Química, Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Avda. Leopoldo Carvallo 270, Playa Ancha, Valparaíso 2340000, Chile
Candida is a genus of yeasts and is the most common cause of fungal infections worldwide. However, only a few antifungal drugs are currently available for the treatment of Candida infections. In the last decade, terpenophenols have attracted much attention because they often possess a variety of biological activities. In the search for new antifungals, eight carveoylphenols were synthesized and characterized by spectroscopic analysis. By using the broth microdilution assay, the compounds were evaluated for antifungal activities in vitro against four human pathogenic yeast, and structure−activity relationships (SAR) were derived. Noteworthy, in this preliminary study, compounds 5 and 6, have shown a significant reduction in the growth of all Candida strains tested. Starting from these preliminary results, we have designed the second generation of analogous in this class, and further studies are in progress in our laboratories.