In Situ Hybridization for the Identification of Karyotype Anomalies in the Histological Analysis of Early Spontaneous Abortion

Abstract

An estimated 15% of known pregnancies terminate in spontaneous abortion, the majority (90% circa) within the XII° week of gestation: early spontaneous abortion (ESA). Spontaneous abortions are either occasional (first abortion in the patient’s reproductive history), repeated (the second) or habitual (third or more).The possible causes are many, but about half are due to alterations in embryonic karyotype – 27% trisomy, 10% polipolidy, 9% monosomy and 2% structural rearrangements [1]. With histological examination a morphological diagnosis of chromosomal anomalies may be suspected, based on structural anomalies of the villous tree or alterations in vascularization, but a cytogenetic confirmation is required [2]. [...]