Gęstość mammograficzna piersi a leczenie hormonalne w okresie pomenopauzalnym

Abstract

High criteria of mammographic breast density are the risk factor of breast cancer occurrence. Numerousresearch papers report that the estrogenic-progestagenic therapy, especially in continuous schema, results innipple density increase up to 3-6%. Moreover, the literature states that the estrogenic therapy does not causethe increase of MBD. The type of gestagen used seems not to have any influence on breast density, however,estrogen dosage and the age at which the hormonal replacement therapy has been introduced, play crucial role.In most patients from the group of high risk of breast cancer and those treated because of this reason, the useof tamoxifen reduces statistically breast density. Other drugs such as raloxifene or letrozole indicate a decreaseof mammographic breast density similar to placebo.

Keywords

• mammographic breast density
• breast cancer
• hormonal therapy
• tamoxifen
• letrozole