Nature Communications (Jan 2018)

Yolk sac macrophage progenitors traffic to the embryo during defined stages of development

  • C. Stremmel,
  • R. Schuchert,
  • F. Wagner,
  • R. Thaler,
  • T. Weinberger,
  • R. Pick,
  • E. Mass,
  • H. C. Ishikawa-Ankerhold,
  • A. Margraf,
  • S. Hutter,
  • R. Vagnozzi,
  • S. Klapproth,
  • J. Frampton,
  • S. Yona,
  • C. Scheiermann,
  • J. D. Molkentin,
  • U. Jeschke,
  • M. Moser,
  • M. Sperandio,
  • S. Massberg,
  • F. Geissmann,
  • C. Schulz

DOI
https://doi.org/10.1038/s41467-017-02492-2
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 14

Abstract

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Tissue-resident macrophages are derived from yolk sac progenitors but how and when these progenitors enter is unclear. Here the authors use fate mapping and intravital microscopy to track the movement of resident macrophage precursors from the yolk sac to fetal tissues during development.