Nature Communications (Mar 2023)
Short-term molecular consequences of chromosome mis-segregation for genome stability
- Lorenza Garribba,
- Giuseppina De Feudis,
- Valentino Martis,
- Martina Galli,
- Marie Dumont,
- Yonatan Eliezer,
- René Wardenaar,
- Marica Rosaria Ippolito,
- Divya Ramalingam Iyer,
- Andréa E. Tijhuis,
- Diana C. J. Spierings,
- Michael Schubert,
- Silvia Taglietti,
- Chiara Soriani,
- Simon Gemble,
- Renata Basto,
- Nick Rhind,
- Floris Foijer,
- Uri Ben-David,
- Daniele Fachinetti,
- Ylli Doksani,
- Stefano Santaguida
Affiliations
- Lorenza Garribba
- Department of Experimental Oncology at IEO, European Institute of Oncology IRCCS
- Giuseppina De Feudis
- Department of Experimental Oncology at IEO, European Institute of Oncology IRCCS
- Valentino Martis
- Department of Experimental Oncology at IEO, European Institute of Oncology IRCCS
- Martina Galli
- IFOM ETS - The AIRC Institute of Molecular Oncology
- Marie Dumont
- Institut Curie, PSL Research University, CNRS
- Yonatan Eliezer
- Department of Human Molecular Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University
- René Wardenaar
- European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen
- Marica Rosaria Ippolito
- Department of Experimental Oncology at IEO, European Institute of Oncology IRCCS
- Divya Ramalingam Iyer
- Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School
- Andréa E. Tijhuis
- European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen
- Diana C. J. Spierings
- European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen
- Michael Schubert
- European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen
- Silvia Taglietti
- Department of Experimental Oncology at IEO, European Institute of Oncology IRCCS
- Chiara Soriani
- Department of Experimental Oncology at IEO, European Institute of Oncology IRCCS
- Simon Gemble
- Institut Curie, PSL Research University, CNRS
- Renata Basto
- Institut Curie, PSL Research University, CNRS
- Nick Rhind
- Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School
- Floris Foijer
- European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen
- Uri Ben-David
- Department of Human Molecular Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University
- Daniele Fachinetti
- Institut Curie, PSL Research University, CNRS
- Ylli Doksani
- IFOM ETS - The AIRC Institute of Molecular Oncology
- Stefano Santaguida
- Department of Experimental Oncology at IEO, European Institute of Oncology IRCCS
- DOI
- https://doi.org/10.1038/s41467-023-37095-7
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 17
Abstract
Chromosomal instability leads to aneuploidy, a state of karyotype imbalance. By inducing controlled chromosome mis-segregation, Santaguida and colleagues show that aneuploidy can also instigate chromosomal instability.
