Relationships of apolipoprotein E genotypes with a cluster of seven in persons with type 2 diabetes

Abstract

The objective of the study was to determine if there would be statistically significant differences or trends among apolipoprotein E genotypes (2/2, 2/3, 2/4, 3/3, 3/4, and 4/4) for each member of the cluster of seven associated with type 2 diabetes (T2D). The cluster of seven includes abdominal obesity, hypertension, platelet hyperaggregability, hyperglycemia, dyslipidemia (decreased plasma levels of high-density lipoprotein cholesterol (HDL-C) and increased plasma levels of triglycerides)), increased low-density lipoprotein (LDL) oxidation, and increased inflammation.

Keywords

• apolipoprotein e genotype polymorphisms
• waist circumference
• blood pressure
• bleeding time
• plasma glucose
• hdl-cholesterol
• triglycerides
• ldl conjugated dienes
• c-reactive protein